Thursday, October 1, 2009

What is the relationship between HIV AIDS and Leukemia

What is the relationship between HIV AIDS and Leukemia?
Can one be the causative factor for another? How?
STDs - 3 Answers
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1 :
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2 :
Yes, very good question. Many people, even medical professionals aren't aware of the relationship. Leukemia is basically abnormal white blood cells.. typically immature. But the gross definition is 'abnormal white blood cells'. This abnormality causes the symptoms and problems associated with leukemia. Which is why blood transfusions and current therapies work in the way they do. HIV is a completely different entity -- so how on earth are they related? Well quite simply HIV infection causes an imbalance in growth factors. Some of these growth factors and hormones cause bone marrow cells to grow. On occasion (in fact it's only on a very rare occasion) some of these bone marrow cells grow and become leukemic. (In case you aren't aware, the bone marrow produces the blood cells... in this case white blood cells. So you alter the creator of the cell, the cells will be created abnormally, hence leukemia.) Example of growth factor is IGF-1 -- bodybuilders often use a growth factor for lean muscle mass,.. at the risk of predisposing themselves to carcinogenic activity. Hope that helps.
3 :
1. HIV is a virus that attacks CD4 T Cells (one of 2 T cells CD4 and CD8). Essentially what will happen is that over time the virus will eliminate all of the CD4 T Cells (you will still have CD8 T cells "the other type"). CD4 T cells have 2 functions: they stimulate the activation of B cell secretion of antibodies and they recruit other immune cells (macrophages) to destroy pathogens. Once CD4 T cells reach a low level a huge chunk of the adaptive immune system is not protecting the individual so an HIV patient usually succumbs to opportunistic pathogens that typically don't cause harm in individuals with functional CD4 T Cells. (Acquired Immune Deficiency Syndrome = gradual loss of CD4 T Cells). 2. Leukemia is cancer of the blood or bone marrow. It's a general term and can be distinguished by cancer of any of the leukocytes to include CD4 T cells. There are many different types and causes of leukemia, one of which is caused by a virus that targets CD4 T cells. If it was my HW, I would say that both HIV and Leukemia affect leukocytes (general term = white blood cells) and result in a decreased adaptive (humoral) immune response. Individuals with HIV (and other virus infections) are at a HIGHER RISK of developing certain leukemias.

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